The energy released when the protons flow back into the mitochondrial interior is used to form ATP (Figure 2) (1). In addition to its role in ATP synthesis, mitochondrial coenzyme Q10 mediates the oxidation of dihydroorotate to orotate in the de novo pyrimidine synthesis.

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1/2 Statin-associated cognitive decline is a real entity. Likely mechanisms to explain the adverse effects include - Reduction of synthesis of coenzyme Q10 with consequent increasing oxidative stress and reduction of cerebral energy production;

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